Ep. 347 Expanding Perspectives on LDL, Lipids, and LMHRs with Dave Feldman

I am honored to reconnect with Dave Feldman today. Our last encounter was in December 2020, for Episode 128, where we delved deeply into the topic of cholesterol.
Dave is an engineer by profession. He is profoundly clever and commands great respect within the low-carb and keto community due to his willingness to challenge prevailing narratives, encouraging us to explore alternative perspectives on lipid metabolism and reconsider our understanding of LDL, particularly in the context of lean mass hyper-responders like myself.
In our discussion today, we dive into how LDL became so vilified, with Dave shedding light on several crucial research findings. We explain what low-mass hyper-responders are, examine biases and cognitive dissonance, touch on Dave’s new LMHR study, and discuss the Miami Heart study, a longitudinal study of the roles of LDL and plaque burden. We also explore the impact of ApoB and reflect on the essence of science as a pursuit of truth, and Dave shares what lies ahead for himself and his research.
I trust you will find this conversation engaging and thought-provoking.

Ep. 336 Lipid Masterclass: An Introduction to Lipids and Cholesterol with Dr. Thomas Dayspring

Today, I am excited to share the first class in a series of lipid masterclasses with the amazing Dr. Thomas Dayspring!
Dr. Dayspring is certified in internal medicine and clinical epidemiology and is a fellow of the American College of Physicians and the National Lipid Association. He was previously the Educational Director of a nonprofit organization and has served as the Chief Academic Advisor for two major cardiovascular labs.
Due to the in-depth nature of my discussions with Dr. Dayspring over several sessions, each lasting nearly six hours, it seemed logical to present these masterclasses in segmented chunks to make them easier to understand.
In our first class today, we dive into the fundamentals, exploring what lipids are and how lipids and fatty acids are classified. We cover the physiology and transportation of cholesterol and the role of apoptosis, apo-proteins, and apo-lipoproteins, unravel the differences between HDL, LDL, IDL, and VLDL, and explain how to calculate LDLs and triglycerides for assessing metabolic health. Dr. Dayspring also shares his preferences regarding lab values and the indicators that provide information to help him determine the early risk of cardiovascular disease.
We get into some detailed aspects of physical chemistry in this episode, so I highlight the main clinical points throughout our conversation to make it more understandable.
Be sure to join Dr. Dayspring and me for our next episode in the lipid masterclass series.